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Dolly was also not entirely identical to her genetic mother because the mitochondria, the power plants of the cell that are kept outside the nucleus, were inherited from Dolly’s egg donor mother.
Dolly the sheep, as the first mammal to be cloned from an adult cell, is by far the world's most famous clone.
However, cloning has existed in nature since the dawn of life.
The DNA in the nucleus is wrapped up into chromosomes, which shorten each time the cell replicates.
This meant that Dolly’s chromosomes were a little shorter than those of other sheep her age and her early ageing may reflect that she was raised from the nucleus of a 6-year old sheep.
This was a major scientific achievement as it demonstrated that the DNA from adult cells, despite having specialised as one particular type of cell, can be used to create an entire organism.
Animal cloning from an adult cell is much more difficult than from an embryonic cell.The treatment is currently not permitted for use in humans.However, the Human Fertilisation & Embryology Authority in the UK has reported that there is general support in the public for legalising the therapy and making it available to patients.So when scientists working at the Roslin Institute in Scotland produced Dolly, the only lamb born from 277 attempts, it was a major news story around the world.To produce Dolly, scientists used an udder cell from a six-year-old Finn Dorset white sheep.About 1 in 6000 people is born with faulty mitochondria, which can result in diseases like muscular dystrophy.To prevent this, genetic material from the embryo is extracted and placed in an egg cell donated by another woman, which contains functioning mitochondria.Born on 5 July 1996, she was euthanased on 14 February 2003, aged six and a half.Sheep can live to age 11 or 12, but Dolly suffered from arthritis in a hind leg joint and from sheep pulmonary adenomatosis, a virus-induced lung tumour that is common among sheep which are raised indoors.The unfertilised egg cell came from a Scottish Blackface ewe.When the research team had managed to fuse the nucleus from the adult white sheep cell with the egg cell from the black-faced sheep, they needed to make sure that the resulting cell would develop into an embryo.