Breast Cancer Literature Review

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We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk.

Data were provided on mutations and polymorphisms associated with BC without fixing a specific date.

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If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ( which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Studies of interest were randomized controlled trials (RCTs) or comparative non-randomized clinical trials (non-RCTs).

Outcomes included survival, disease and pathological response, and adverse events.Thirty-two trials evaluated chemotherapy alone, with the majority assessing chemotherapy combinations of 2 or more subclasses. Thirty-five trials reported treatments on metastatic or advanced TNBC, 31 on neoadjuvant and 11 on adjuvant therapies. By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.Then enter the ‘name’ part of your Kindle email address below. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi.‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.Overall survival (n = 32) and progression-free survival (n = 30) were the most commonly reported efficacy outcomes. Targeted therapies, followed by chemotherapy in forms of combinations of 2 or more subclasses, composed most trials in TNBC, with immunotherapy being rarely used thus far. The trials were mainly conducted in metastatic or advanced setting, followed by neoadjuvant and adjuvant settings. Eighty-nine publications corresponding to 77 unique trials met the eligibility criteria for this review. The 72 RCTs and 5 comparative non-RCTs were predominantly open-label phase 2 or 3 trials.


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